Jaceosidin research studies and benefit for cancer
Jaceosidin induces apoptosis in human ovary cancer
cells through mitochondrial pathway.
J Biomed Biotechnol. 2008; The Second Affiliated Hospital, Women's Hospital,
School of Medicine, Zhejiang University, Hangzhou, China.
We examined the antiproliferation effect of Jaceosidin (4', 5, 7-trihydroxy-3',
6-dimethoxyflavone) isolated from the herb of Artemisia vestita Wall on several
human cancer cell lines. Jaceosidin significantly reduced the proliferation of
CAOV-3, SKOV-3, HeLa, and PC3 cells in a concentration-dependent manner. A
time-dependent inhibition was also observed in CAOV-3 cells by Jaceosidin. By
flow cytometric analysis, we found that Jaceosidin treatment resulted in an
increased apoptosis in CAOV-3 cells. The cells treated with Jaceosidin exhibited
a decreased mitochondrial membrane potential. Jaceosidin elevated the level of
cytochrome c in cytosol. These findings suggest that the anticancer effect of
Jaceosidin may be contributed by an induction of apoptosis involving cytochrome
c release from mitochondria to cytosol.
Inhibitory effect of eupatilin and jaceosidin isolated
from Artemisia princeps on carrageenan-induced inflammation in mice.
J Ethnopharmacol. 2009; Department of Life and Nanopharmaceutical
Sciences and Department of Pharmaceutical Science, Kyung Hee University, Seoul
, Republic of Korea.
Artemisia princeps Pampanini (family Asteraceae) is an herbal medicine widely
used as a hepatoprotective, antioxidative, anti-inflammatory, and antibacterial
agent in Korea, China, and Japan. This study aimed to elucidate the
anti-inflammatory effect of the main constituents, eupatilin and jaceosidin,
isolated from Artemisia princeps. We used carrageenan-induced inflammation in an
air pouch on the back of mice and carrageenan-induced hind paw edema in rats to
determine the anti-inflammatory effects of eupatilin and jaceosidin.
Inflammatory makers, such as expression of pro-inflammatory cytokines and
cyclooxygenase (COX)-2, and activation of nuclear factor-kappa B (NF-kappaB),
were measured by enzyme-linked immunosorbent assays and immunoblot analyses.
Eupatilin and jaceosidin blocked carrageenan-induced increase in
leukocyte number and protein levels in air pouch exudates. Eupatilin and
jaceosidin inhibited COX-2 expression and NF-kappaB activation, and markedly
reduced TNF-alpha, IL-1beta, and prostaglandin E2 (PGE(2)) levels. They also
inhibited hind paw edema induced by carrageenan. Eupatilin and jaceosidin had
similar activity. These findings suggest that eupatilin and jaceosidin may
reduce inflammation by inhibiting NF-kappaB activation, and that Artemisia
princeps inhibits inflammation because of these constituents.
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