Isovitexin flavonoid and review of healing benefits
March 1 2014

Isovitexin is a flavonoid found in many herbs. As of 2014, no human studies with isovitexin supplements could be found on Medline.

Passiflora incarnata herb has isovitexin
The major flavonoids isolated from passiflora incarnata are identified as orientin, isoorientin, vitexin, isovitexin, and schaftoside.

Spasmolytic effect
The spasmolytic effect of Aloysia citriodora, Palau (South American cedrón) is partially due to its vitexin but not isovitexin on rat duodenums.
J Ethnopharmacol. 2007. Cátedra de Farmacología, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
The spasmolytic effects of an acqueous extract of cedrón were studied on rat isolated duodenums. This plant (Aloysia citriodora Palau, Verbenaceae) is widely used for gastrointestinal disorders and as eupeptic in South America. The flavonoid vitexin is partially responsible for the effect, since it non-competitively inhibits Ach but not the Ca(2+) influx. Isovitexin was devoid of activity on duodenums.

Isovitexin and xanthine oxidase
Molecular modeling of flavonoids that inhibits xanthine oxidase.
Biochem Biophys Res Commun. 2002.
The inhibition of xanthine oxidase activity by various flavonoids was assessed. All of the tested flavonoids were competitive inhibitors, and from the kinetic analysis suggested that flavonoids bind to the reactive site. To further understand the stereochemistry between these flavonoids and xanthine oxidase, structure-based molecular modeling was performed. Apigenin was the most potent inhibitor which showed the most favorable interaction in the reactive site.  Isovitexin showed the weakest inhibitory effect among the compounds tested. The bulky group of sugar in isovitexin may hamper its interaction with xanthine oxidase.

Simultaneous determination of four glycosylflavones from Lophatherum gracile by RP-HPLC
Zhongguo Zhong Yao Za Zhi. 2008. Research and Development Certer of Natural Medicine, Zhejiang Forestry University, Lin'an, China.
To develop a RP-HPLC method for simultaneous determination of orientin, isorientin, vitexin and isovitexin in Lophatherum gracile from different habitat and harvesting time. Four components were isolated well, the linear relationships were excellent. The mean recoveries and RSD values of orientin, isorientin, vitexin and isovitexin were 103%, 2%; 101%, 2%; 98%, 2%; 99%, 2%, respectively.

J Agric Food Chem. 2012 Oct 31. Enzymatic acylation of isoorientin and isovitexin from bamboo-leaf extracts with fatty acids and antiradical activity of the acylated derivatives.

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