Integrins research studies and new information

Integrins are a family of transmembrane receptors that mediate cell-cell and cell-matrix adhesion. They are involved in stable cell adhesion and migration of cells. In addition, integrin-mediated interactions modulate the response to most, if not all growth factors, cytokines, and other soluble factors. Integrins can affect the multitude of signal transduction cascades in control of survival, proliferation, and differentiation. Integrins alpha5beta1 and alphanubeta3 are involved in disease and antagonists of these integrins, including disintegrins, RGD peptides, small molecules, and function blocking antibodies, may be of benefit either alone or, especially in the treatment of cancer, in combination with existing treatment strategies.

The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane alphabeta heterodimers and at least 18 alpha and eight beta subunits are known in humans, generating 24 heterodimers. Members of this family have been found in mammals, chicken and zebrafish, as well as lower eukaryotes.

Integrins and lung cancer
The integrin family plays important roles during tumor angiogenesis, the formation of new blood vessels from pre-existing vasculature.

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